rCBV LeakageCorrection application developed by UCLA Brain Tumor Imaging Laboratory of the University of California Los Angeles. rCBV LeakageCorrection is a standalone application developed in Matlab®R2016a.

Current Version: 2.1
Date: 8th November 2016

New Features

1. Allows loading and saving of sequences in DICOM format.
2. Creates the brain mask for the loaded perfusion sequences.
3. Calculates the injection time point for the perfusion sequence loaded.
4. Corrects the perfusion sequence for motion.
5. Registers the results to a T1 post contrast sequence for visualization.

References and Support

For more information:

1. i  Leu K, Boxerman JL, Cloughesy TF, et al. Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange. AJNR American journal of neuroradiology 2016;37:1440-1446
2. ii  Leu K, Boxerman JL, Lai A, et al. Bidirectional Contrast agent leakage correction of dynamic susceptibility contrast (DSC)-MRI improves cerebral blood volume estimation and survival prediction in recurrent glioblastoma treated with bevacizumab. J Magn Reson Imaging 2016

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